Non-Steroidal Anti-Inflammatory Drug (NSAID)-Induced Small Intestinal Injury
نویسنده
چکیده
Nonsteroidal anti-inflammatory drugs (NSAIDs), including lowdose aspirin, are among the most widely prescribed medications, with approximately 30 million patients worldwide ingesting NSAID [1]. NSAID could cause small intestinal injury. It became clear from the studies of post-mortem samplesby Bjarnason and colleagues (1993) that NSAID use is alsoassociated with significant damage to the more distal regionsof the small intestine (i.e. distal to the ligament of Treitz) [2]. Small intestinal injury includes bleeding, erosion, and ulceration [3,4]. Serious complications can includemassive bleeding, perforation and strictures, sometimes leading to death [5]. PubMed with key words “NSAID and enteropathy” was used in 1994 through 2013 for selecting articles. The aim of this short review is to summarize out current understanding of NSAID induced small intestinal injury.
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